(I) Restricting an animal’s calorie intake is the most
famous intervention known to extend life span.
(II) Discovered more than 70 years ago, calorie
restriction is still the only one absolutely proven to have
an effect on it. (III) The restricted regime typically
involves reducing an animal’s food consumption by 30
to 40 per cent compared with what is considered normal
for its species. (IV) Therefore, understanding this
mechanism and developing medicines that reproduce
its health benefits have been goals for decades.
(V) Animals ranging from rats to dogs and possibly
primates that remain on this diet not only live longer but
are far healthier during their prolonged lives.