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Tolerance is a person’s diminished response to a
drug, which occurs when the drug is used
repeatedly and the body adapts to the continued
presence of the drug. For instance, when morphine
or alcohol is used for a long time, larger and larger
doses must be taken to produce the same effect.
Usually, tolerance develops because metabolism of
the drug speeds up and because the number of cell
receptors that the drug attaches to or the strength of
the bond between the receptor and the drug
decreases. ----
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Also, many of the drugs in current use have undergone clinical trials in order to determine the effects of long-term tolerance. |
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If a patient becomes tolerant to a given drug, depending on the degree of tolerance, the doctor may increase the dose or select an alternative drug. |
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However, a drug can be more beneficial when taken orally, and it is well-absorbed from the gastrointestinal tract. |
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The body can also develop tolerance for substances such as antihistamines and aspirin, but these tolerances rarely cause serious problems. |
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In short, people respond to drugs differently due to factors such as age, genetic make-up, diet and pregnancy. |